Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress

@article{McGuire2011DifferentialRO,
  title={Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress},
  author={Jennifer L. McGuire and Lauren E. Larke and Floyd R. Sallee and James P. Herman and Renu Sah},
  journal={Frontiers in Behavioral Neuroscience},
  year={2011},
  volume={5}
}
Accumulating evidence from clinical studies and pre-clinical animal models supports a role for neuropeptide Y (NPY) in adaptive emotional response following stress. The long-term impact of stress, particularly chronic stress, on availability, and function of resilience factors such as NPY may be critical to understanding the etiology of stress-related psychopathology. In these studies, we examined expression of NPY during recovery from a chronic variable stress (CVS) model of repetitive trauma… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
Relevance of neuropeptide Y (NPY) in psychiatry.
TLDR
Impaired central NPY signaling may therefore be involved in the pathophysiology of depression, anxiety, schizophrenia, alcoholism, and trauma-induced disorders like PTSD. Expand
Neuropeptide Y in the Amygdala Induces Long-Term Resilience to Stress-Induced Reductions in Social Responses But Not Hypothalamic–Adrenal–Pituitary Axis Activity or Hyperthermia
TLDR
For the first time, repeated administration of NPY directly into the basolateral nucleus of the amygdala (BLA) produces selective stress-resilient behavioral responses to an acute restraint challenge as measured in the social interaction test, but has no effect on hypothalamic–adrenal–pituitary axis activity or stress-induced hyperthermia. Expand
Interactions between NPY and CRF in the amygdala to regulate emotionality
TLDR
The scientific literature describing the NPY-CRF relationship is reviewed, specifically as it relates to the modulation of the CRF-mediated stress responses via the amygdala, a key forebrain structure involved in the regulation of emotional states. Expand
Genetic variation in human NPY expression affects stress response and emotion
TLDR
It is shown that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety, consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress. Expand
The NPY system in stress, anxiety and depression
  • M. Heilig
  • Medicine, Psychology
  • Neuropeptides
  • 2004
TLDR
Information is provided on several brain structures involved in mediating anti-stress actions of NPY, with the most extensive evidence available for amygdala and hippocampus, and some evidence for regions within the septum, and locus coeruleus. Expand
Effects of single-prolonged stress on neurons and their afferent inputs in the amygdala
TLDR
It is suggested that changes in the morphology of pyramidal neurons in the BLA by SPS could be mediated through the enhancement of NPY functions, and this structural plasticity in the amygdala provides a cellular and molecular basis to understand for affective disorders. Expand
Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress
TLDR
The present findings support the hypothesis that anxiety related behavioral effects of stress may in part be mediated through modulation of NPY function in the amygdala. Expand
Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress
TLDR
Interestingly, the CRH neurons in both PVN and central nucleus of the amygdala (CeA) were stimulated by CUMS, and may both contribute to depression-like behaviors during CUMS. Expand
Behavioral and endocrine adaptation, and up-regulation of NPY expression in rat amygdala following repeated restraint stress.
TLDR
Following repeated restraint, an up-regulation of NPY expression in the amygdala complex may be an adaptive mechanism recruited to cope with a repeated stressor. Expand
Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder
TLDR
Men with combat-related PTSD have low CSF concentrations of the putative resiliency hormone NPY, possibly related to the disorder or to extreme stress exposure per se. Expand
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2
3
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5
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