Differential Regulation of Human and Mouse Myometrial Contractile Activity by FSH as a Function of FSH Receptor Density.

@article{Stilley2016DifferentialRO,
  title={Differential Regulation of Human and Mouse Myometrial Contractile Activity by FSH as a Function of FSH Receptor Density.},
  author={Julie A. W. Stilley and Rongbin Guan and Donna A. Santillan and Bryan F. Mitchell and Kathryn G. Lamping and Deborah L Segaloff},
  journal={Biology of reproduction},
  year={2016},
  volume={95 2},
  pages={36}
}
Previous studies from our laboratory revealed that the follicle-stimulating hormone receptor (FSHR) is expressed at low levels in nonpregnant human myometrium and that it is up-regulated in pregnant term nonlaboring myometrium; however, the physiological relevance of these findings was unknown. Herein, we examined signaling pathways stimulated by FSH in immortalized uterine myocytes expressing recombinant FSHR at different densities and showed that cAMP accumulation is stimulated in all cases… CONTINUE READING
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