Differential Regulation of Granule-to-Granule and Granule-to-Plasma Membrane Fusion during Secretion from Rat Pituitary Lactotrophs

@article{Cochilla2000DifferentialRO,
  title={Differential Regulation of Granule-to-Granule and Granule-to-Plasma Membrane Fusion during Secretion from Rat Pituitary Lactotrophs},
  author={Amanda J. Cochilla and Joseph K. Angleson and William J. Betz},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={839 - 848}
}
We used fluorescence imaging of individual exocytic events together with electron microscopy to study the regulation of dense core granule-to-plasma membrane fusion and granule-to-granule fusion events that occur during secretion from rat pituitary lactotrophs. Stimulating secretion with elevated extracellular potassium, with the calcium ionophore ionomycin, or with thyrotropin releasing hormone or vasoactive intestinal polypeptide resulted in abundant exocytic structures. Approximately 67% of… CONTINUE READING
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