Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

@article{Kim2013DifferentialRO,
  title={Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy},
  author={Joungmok Kim and Young Chul Kim and Chong Fang and Ryan Charles Russell and Jeong Hee Kim and Weiliang Fan and R Liu and Qing Zhong and Kun Liang Guan},
  journal={Cell},
  year={2013},
  volume={152},
  pages={290-303}
}
Autophagy is a stress response protecting cells from unfavorable conditions, such as nutrient starvation. The class III phosphatidylinositol-3 kinase, Vps34, forms multiple complexes and regulates both intracellular vesicle trafficking and autophagy induction. Here, we show that AMPK plays a key role in regulating different Vps34 complexes. AMPK inhibits the nonautophagy Vps34 complex by phosphorylating T163/S165 in Vps34 and therefore suppresses overall PI(3)P production and protects cells… CONTINUE READING
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