Differential Regional Distribution of Enterostatin, an Appetite Inhibiting Peptide, in the Brains of Zucker and Sprague-Dawley Rats.

@article{Imamura1998DifferentialRD,
  title={Differential Regional Distribution of Enterostatin, an Appetite Inhibiting Peptide, in the Brains of Zucker and Sprague-Dawley Rats.},
  author={Makoto Imamura and Johnny R. Porter and Chandan Prasad},
  journal={Nutritional neuroscience},
  year={1998},
  volume={1 6},
  pages={449-53}
}
Enterostatins are pentapeptides represented at the amino-terminus of procolipase molecule. Val-Pro-Asp-Pro-Arg or VPDPR is one such enterostatin. Pharmacologic studies suggest a role for VPDPR in appetite regulation and insulin secretion; however, due to the lack of a suitable assay method, the function of endogenous peptide has not been possible to discern until now. In the present investigation, we have shown the presence of a VPDPR-like immunoreactivity (VPDPR-LI) in the rat brain. On… CONTINUE READING

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