Differential Recognition of β-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2 (*)

@article{Ganapathy1995DifferentialRO,
  title={Differential Recognition of $\beta$-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2 (*)},
  author={M. E. Ganapathy and M. Brandsch and P. Prasad and V. Ganapathy and F. Leibach},
  journal={The Journal of Biological Chemistry},
  year={1995},
  volume={270},
  pages={25672 - 25677}
}
This study was initiated to determine if there are differences in the recognition of β-lactam antibiotics as substrates between intestinal and renal peptide transporters, PEPT 1 and PEPT 2. Reverse transcription-coupled polymerase chain reaction and/or Northern blot analysis have established that the human intestinal cell line Caco-2 expresses PEPT 1 but not PEPT 2, whereas the rat proximal tubule cell line SKPT expresses PEPT 2 but not PEPT 1. Detailed kinetic analysis has provided unequivocal… Expand
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