Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D*

@inproceedings{Davydova2016DifferentialRB,
  title={Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D*},
  author={Natalia Davydova and Nicole C Harris and Sally Roufail and Sophie Paquet-Fifield and Musarat Ishaq and Victor A Streltsov and Steven P Williams and Tara Karnezis and Steven A Stacker and Marc G. Achen},
  booktitle={The Journal of biological chemistry},
  year={2016}
}
VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics. VEGF-C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated distinct signaling mechanisms (e.g. tumor-derived VEGF-C promoted expression of the prostaglandin… CONTINUE READING