Differential RNA fingerprinting as a tool in the analysis of spermatozoal gene expression.

@article{Miller1994DifferentialRF,
  title={Differential RNA fingerprinting as a tool in the analysis of spermatozoal gene expression.},
  author={Dr. Nick Miller and Peng-zhi Tang and Craig S. Skinner and Richard J. Lilford},
  journal={Human reproduction},
  year={1994},
  volume={9 5},
  pages={
          864-9
        }
}
The apparent decline in human male fertility and the concomitant increase in testicular pathology have prompted discussion of the underlying molecular mechanisms which may underpin these observations. While monitoring the expression of protamine-2 genes in the human ejaculate, we found a representative complement of sperm mRNAs following sequence-independent amplification of reverse-transcribed cDNAs with the polymerase chain reaction (RT-PCR). The revelation of unique sperm-derived PCR… CONTINUE READING
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