Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination

@inproceedings{Dobao2019DifferentialPO,
  title={Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination},
  author={Carlota Doba{\~n}o and Rebeca Santano and Marta Segarra Vidal and A. B. Pozuelo Jim{\'e}nez and Chenjerai Jairoce and Itziar Ubillos and David Dosoo and Ruth Aguilar and Nana Aba Williams and N{\'u}ria D{\'i}ez-Padrisa and Aintzane Ayestaran and Clarissa Valim and Kwaku Poku Asante and Seth Owusu-Agyei and David E. Lanar and Virander S. Chauhan and Chetan E. Chitnis and Sheetij Dutta and Evelina Angov and Beno{\^i}t Gamain and Ross L. Coppel and James G Beeson and Linda Reiling and Deepak Gaur and David Ph. D. Cavanagh and Ben Gyan and Augusto J. Nhabomba and Joseph J Campo and Gemma Moncunill},
  booktitle={Front. Immunol.},
  year={2019}
}
Naturally acquired immunity (NAI) to Plasmodium falciparum malaria is mainly mediated by IgG antibodies but the subclasses, epitope targets and effector functions have not been unequivocally defined. Dissecting the type and specificity of antibody responses mediating NAI is a key step toward developing more effective vaccines to control the disease. We investigated the role of IgG subclasses to malaria antigens in protection against disease and the factors that affect their levels, including… CONTINUE READING
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