Differential Notch signalling distinguishes neural stem cells from intermediate progenitors.

@article{Mizutani2007DifferentialNS,
  title={Differential Notch signalling distinguishes neural stem cells from intermediate progenitors.},
  author={Ken-Ichi Mizutani and Keejung Yoon and Louis Dang and Akinori Tokunaga and Nicholas R. Gaiano},
  journal={Nature},
  year={2007},
  volume={449 7160},
  pages={
          351-5
        }
}
During brain development, neurons and glia are generated from a germinal zone containing both neural stem cells (NSCs) and more limited intermediate neural progenitors (INPs). The signalling events that distinguish between these two proliferative neural cell types remain poorly understood. The Notch signalling pathway is known to maintain NSC character and to inhibit neurogenesis, although little is known about the role of Notch signalling in INPs. Here we show that both NSCs and INPs respond… CONTINUE READING
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