Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals.

@article{Rutjens2007DifferentialNI,
  title={Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals.},
  author={Erik Rutjens and Stefania Mazza and Roberto Biassoni and Gerrit Jan Koopman and Luana Radi{\'c} and Manuela Fogli and Paola F. da Costa and Maria Cristina Mingari and Lorenzo Moretta and Jonathan Luke Heeney and Andrea de Maria},
  journal={Journal of immunology},
  year={2007},
  volume={178 3},
  pages={
          1702-12
        }
}
HIV-1 infection in chimpanzees, the closest human relative, rarely leads to disease progression. NK cells contribute to the shaping of adaptive immune responses in humans and show perturbed phenotype and function during HIV-1 infection. In this study, we provide full phenotypic, molecular, and functional characterization for triggering molecules (NKp46, NKp30 NKp80, and NKG2D) on Pan troglodytes NK cells. We demonstrate that, in this AIDS-resistant species, relevant differences to human NK… CONTINUE READING
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