Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration

@inproceedings{Cleva2011DifferentialMO,
  title={Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration},
  author={Richard M. Cleva and Lucas R Watterson and Meagan A. Johnson and M Foster Olive},
  booktitle={Front. Pharmacol.},
  year={2011}
}
Pharmacological manipulation of the type 5 metabotropic glutamate (mGlu5) receptor alters various addiction related behaviors such as drug self-administration and the extinction and reinstatement of drug-seeking behavior. However, the effects of pharmacological modulation of mGlu5 receptors on brain reward function have not been widely investigated. We examined the effects of acute administration of positive and negative allosteric modulators (PAMs and NAMs, respectively) on brain reward… CONTINUE READING
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Differential modulation of thresholds for intracranial self-stimulation by mGlu5

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