Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling

@inproceedings{Luhmann2012DifferentialMO,
  title={Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling},
  author={Ulrich F. O. Luhmann and Clemens A Lange and Scott J. Robbie and Peter M. G. Munro and Jill A. Cowing and Hannah E. J. Armer and Vy Luong and L{\'i}via dos S. Carvalho and Robert E Maclaren and Frederick W. Fitzke and James W B Bainbridge and Robin R Ali},
  booktitle={PloS one},
  year={2012}
}
Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses. Defining the role of Ccl2-Ccr2 and Cx3cl1-Cx3cr1 signalling for retinal pathology is of particular interest because of its potential role in age-related macular degeneration (AMD). Ccl2, Ccr2, and Cx3cr1 signalling defects impair macrophage trafficking, but have, in several conflicting studies, been reported to show different… CONTINUE READING