Differential Modulation of Glutamatergic Transmission by 3,5-Dibromo-l-phenylalanine

  title={Differential Modulation of Glutamatergic Transmission by 3,5-Dibromo-l-phenylalanine},
  author={Viktor Yarotskyy and Alexander V. Glushakov and Colin Sumners and Nikolaus Gravenstein and Donn M. Dennis and Christoph N. Seubert and Anatoly E. Martynyuk},
  journal={Molecular Pharmacology},
  pages={1648 - 1654}
An increasing body of evidence supports the hypothesis that diminished function of N-methyl-d-aspartate (NMDA) receptors and the associated increase in glutamate release and overstimulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors are critical elements of the pathophysiology of schizophrenia. Here, we describe a halogenated derivative of the aromatic amino acid l-phenylalanine that 1) activates NMDA receptors, 2) depresses presynaptic glutamate release… 

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