Differential Modulation of Gene Expression Encoding Hepatic and Renal Xenobiotic Metabolizing Enzymes by an Aspalathin-Enriched Rooibos Extract and Aspalathin

@article{Abrahams2018DifferentialMO,
  title={Differential Modulation of Gene Expression Encoding Hepatic and Renal Xenobiotic Metabolizing Enzymes by an Aspalathin-Enriched Rooibos Extract and Aspalathin},
  author={Sameega Abrahams and Sedicka Samodien and Mariska Lilly and Elizabeth Joubert and Wentzel C. A. Gelderblom},
  journal={Planta Medica},
  year={2018},
  volume={85},
  pages={6 - 13}
}
Abstract Modulation of the expression of hepatic and renal genes encoding xenobiotic metabolizing enzymes by an aspalathin-enriched green rooibos (Aspalathus linearis) extract (GRE) was investigated in the liver and kidneys of F344 rats following dietary exposure of 28 d, as well as selected xenobiotic metabolizing genes in rat primary hepatocytes. In the liver, GRE upregulated genes (p < 0.05) encoding aldehyde dehydrogenase, glucose phosphate isomerase, and cytochrome P450 while 17… 
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Differential Cytotoxicity of Rooibos and Green Tea Extracts against Primary Rat Hepatocytes and Human Liver and Colon Cancer Cells – Causal Role of Major Flavonoids

Differential cell responses were noticed with HepG2 cells more sensitive than PH toward the induction of apoptosis by GRE, and HT-29 cells were resistant to apoptosis induction by the tea and pure flavonoids.

The toxic contaminants of Aspalathus linearis plant material as well as herb–drug interactions may constitute the health risk factors in daily rooibos tea consumers

  • J. Pyrzanowska
  • Medicine, Biology
    International journal of environmental health research
  • 2021
Rooibos tea is brewed using Aspalathus linearis plant material sensitive to environmental contamination, yet several human case reports suggest possible acute hepatic damage, so caution should be exercised in patients receiving the treatment with allopathic medicines to avoid untoward alteration of drug plasma concentration.

Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)

The history and gaps are explored with regards to collating aspects of the synthesis, quality control, metabolism and various biological activities of the molecule to fill gaps in the scientific literature available on aspalathin.

Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)

The history and fill gaps with regards to collating aspects of the synthesis, quality control, metabolism and various biological activities of the molecule are explored to explore the history and fills gaps in the scientific literature available on aspalathin.

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Modulation of hepatic drug metabolizing enzymes and oxidative status by rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), green and black (Camellia sinensis) teas in rats.

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Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on Cytochromes Metabolizing Hypoglycemic and Hypolipidemic Drugs

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The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and estrogen quinones has been postulated to be a factor in mammary…