Differential Modulation of Gene Expression Encoding Hepatic and Renal Xenobiotic Metabolizing Enzymes by an Aspalathin-Enriched Rooibos Extract and Aspalathin.

@article{Abrahams2019DifferentialMO,
  title={Differential Modulation of Gene Expression Encoding Hepatic and Renal Xenobiotic Metabolizing Enzymes by an Aspalathin-Enriched Rooibos Extract and Aspalathin.},
  author={S. Abrahams and S. Samodien and M. Lilly and E. Joubert and W. Gelderblom},
  journal={Planta medica},
  year={2019},
  volume={85 1},
  pages={
          6-13
        }
}
Modulation of the expression of hepatic and renal genes encoding xenobiotic metabolizing enzymes by an aspalathin-enriched green rooibos (Aspalathus linearis) extract (GRE) was investigated in the liver and kidneys of F344 rats following dietary exposure of 28 d, as well as selected xenobiotic metabolizing genes in rat primary hepatocytes. In the liver, GRE upregulated genes (p < 0.05) encoding aldehyde dehydrogenase, glucose phosphate isomerase, and cytochrome P450 while 17β-hydroxysteroid… Expand
Differential Cytotoxicity of Rooibos and Green Tea Extracts against Primary Rat Hepatocytes and Human Liver and Colon Cancer Cells - Causal Role of Major Flavonoids.
TLDR
Differential cell responses were noticed with HepG2 cells more sensitive than PH toward the induction of apoptosis by GRE, and HT-29 cells were resistant to apoptosis induction by the tea and pure flavonoids. Expand
Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)
Aspalathin (2′,3,4,4′,6′-pentahydroxy-3′- C - β -D-glucopyranosyldihydrochalcone) is a natural C -linked glucosyl dihydrochalcone present in Aspalathus linearis (Burm.f.) R.Dahlgren (rooibos), aExpand

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