Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

@inproceedings{Lukovac2014DifferentialMB,
  title={Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids},
  author={Sabina Lukovac and Clara Belzer and Linette P Pellis and Bart Keijser and Willem M de Vos and Roy C. Montijn and Guus Roeselers},
  booktitle={mBio},
  year={2014}
}
UNLABELLED The gut microbiota is essential for numerous aspects of human health. However, the underlying mechanisms of many host-microbiota interactions remain unclear. The aim of this study was to characterize effects of the microbiota on host epithelium using a novel ex vivo model based on mouse ileal organoids. We have explored the transcriptional response of organoids upon exposure to short-chain fatty acids (SCFAs) and products generated by two abundant microbiota constituents, Akkermansia… CONTINUE READING
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