Differential Mode of Regulation of the Checkpoint Kinases CHK1 and CHK2 by Their Regulatory Domains*

@article{Ng2004DifferentialMO,
  title={Differential Mode of Regulation of the Checkpoint Kinases CHK1 and CHK2 by Their Regulatory Domains*},
  author={Chuen-Pei Ng and Hung-chiu. Lee and C. Ho and T. Arooz and W. Y. Siu and A. Lau and R. Poon},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={8808 - 8819}
}
CHK1 and CHK2 are key mediators that link the machineries that monitor DNA integrity to components of the cell cycle engine. Despite the similarity and potential redundancy in their functions, CHK1 and CHK2 are unrelated protein kinases, each having a distinctive regulatory domain. Here we compare how the regulatory domains of human CHK1 and CHK2 modulate the respective kinase activities. Recombinant CHK1 has only low basal activity when expressed in cultured cells. Surprisingly, disruption of… Expand
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