Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands*

@article{FernndezMessina2010DifferentialMO,
  title={Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands*},
  author={Lola Fern{\'a}ndez-Messina and Omodele Ashiru and Philippe Boutet and Sonia Ag{\"u}era-Gonz{\'a}lez and Jeremy N. Skepper and Hugh T. Reyburn and Mar Val{\'e}s-G{\'o}mez},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={8543 - 8551}
}
  • Lola Fernández-Messina, Omodele Ashiru, +4 authors Mar Valés-Gómez
  • Published 2010
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • Tumor cells release NKG2D ligands to evade NKG2D-mediated immune surveillance. The purpose of our investigation was to explore the cellular mechanisms of release used by various members of the ULBP family. Using biochemical and cellular approaches in both transfectant systems and tumor cell lines, this paper shows that ULBP1, ULBP2, and ULBP3 are released from cells with different kinetics and by distinct mechanisms. Whereas ULBP2 is mainly shed by metalloproteases, ULBP3 is abundantly released… CONTINUE READING

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