Differential Mechanisms Underlying Antidepressant Responses of Ketamine and Imipramine.


BACKGROUND & OBJECTIVE Ketamine, a noncompetitive NMDA receptor antagonist, exhibits rapid antidepressant actions, but the underlying mechanism remains obscure. AMPA receptor and cAMP response element-binding protein (CREB) are involved in the antidepressant actions of Ketamine and imipramine, a traditional tricyclic antidepressant. However, ketamine exerts… (More)
DOI: 10.2174/1871527316666170428123248