Differential Maturation of the Innate Immune Response in Human Fetuses

  title={Differential Maturation of the Innate Immune Response in Human Fetuses},
  author={Tobias Strunk and Petra Temming and Ulrich G Gembruch and Irwin K H Reiss and Peter Bucsky and Christian Schultz},
  journal={Pediatric Research},
Newborns and especially preterm infants show a unique susceptibility to severe bacterial infections that cause significant morbidity and mortality. As very few data are available on innate immune functions in human fetuses, we conducted a comprehensive study to investigate the expression of several adhesion molecules essentially involved in migration (CD11a, CD11b, CD11c, CD18, and CD62L). Furthermore, phagocytic activity, generation of respiratory burst products, and production of several… CONTINUE READING


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