Differential MRI pattern in CADASIL and hypertensive leukoencephalopathy

  title={Differential MRI pattern in CADASIL and hypertensive leukoencephalopathy},
  author={D P Auer and Benno Puetz and Carsten Goessl and G K Elbel and Martin Dichgans},
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited microangiopathy characterized by recurrent ischemic episodes and cognitive deficits caused by mutations in the Notch3 gene on chromosome 19. Main pathological alterations are found in leptomeningeal and long perforating arteries showing a nonarteriosclerotic, amyloid-negative angiopathy. One of the leading diagnostic criteria that also served for definition of disease carriers in… CONTINUE READING
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