Differential MMP-2 activity of ligament cells under mechanical stretch injury: an in vitro study on human ACL and MCL fibroblasts.

@article{Zhou2005DifferentialMA,
  title={Differential MMP-2 activity of ligament cells under mechanical stretch injury: an in vitro study on human ACL and MCL fibroblasts.},
  author={David Zhou and Hwa Sung Lee and Francisco Villarreal and Annabelle Teng and Erick Lu and Shirley A. Reynolds and Chuan Qin and Joel R Smith and K. L. Paul Sung},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2005},
  volume={23 4},
  pages={949-57}
}
Recent studies have revealed that following injuries, ligament tissues such as anterior cruciate ligaments (ACL), release large amounts of matrix metalloproteinases (MMPs). These enzymes have a devastating effect on the healing process of the injured ligaments. Although these enzymes are produced following ligament injuries, because of different healing capacities seen between the medial collateral ligament (MCL) and ACL, we were curious to find if the MMP activity was expressed and modulated… CONTINUE READING
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