Differential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations.

  title={Differential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations.},
  author={Meghan E. Clements and Michael Gershenovich and Christopher J. Chaber and Juanita Campos-Rivera and Pan Du and Mindy Zhang and S. Ledbetter and Anna Karolina Zuk},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={27 1},
Macrophages are a heterogeneous cell type implicated in injury, repair, and fibrosis after AKI, but the macrophage population associated with each phase is unclear. In this study, we used a renal bilateral ischemia-reperfusion injury mouse model to identify unique monocyte/macrophage populations by differential expression of Ly6C in CD11b(+) cells and to define the function of these cells in the pathophysiology of disease on the basis of microarray gene signatures and reduction strategies… CONTINUE READING
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