Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization

@article{Navarro1998DifferentialLO,
  title={Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization },
  author={Mar{\'i}a del Pilar Navarro and LuigiP. Ruco and Elisabetta Dejana},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={140},
  pages={1475 - 1484}
}
The two major cadherins of endothelial cells are neural (N)-cadherin and vascular endothelial (VE)- cadherin. Despite similar level of protein expression only VE-cadherin is located at cell-cell contacts, whereas N-cadherin is distributed over the whole cell membrane. Cotransfection of VE-cadherin and N-cadherin in CHO cells resulted in the same distribution as that observed in endothelial cells indicating that the behavior of the two cadherins was not cell specific but related to their… CONTINUE READING

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