Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors.

@article{Spaan2015DifferentialIO,
  title={Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors.},
  author={Andr{\'a}s N Spaan and Ari{\"e}n Schiepers and Carla J. C. de Haas and Davy D J J van Hooijdonk and C{\'e}dric Badiou and Hugues Contamin and François Vandenesch and G{\'e}rard Lina and Norma P. Gerard and Craig J. Gerard and Kok P. M. van Kessel and Thomas Henry and Jos A. G. van Strijp},
  journal={Journal of immunology},
  year={2015},
  volume={195 3},
  pages={1034-43}
}
Staphylococcus aureus is well adapted to the human host. Evasion of the host phagocyte response is critical for successful infection. The staphylococcal bicomponent pore-forming toxins Panton-Valentine leukocidin LukSF-PV (PVL) and γ-hemolysin CB (HlgCB) target human phagocytes through interaction with the complement receptors C5aR1 and C5aR2. Currently, the apparent redundancy of both toxins cannot be adequately addressed in experimental models of infection because mice are resistant to PVL… CONTINUE READING
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Complete nucleotide sequence and molecular characterization of the temperate staphylococcal bacteriophage phiPVL carrying Panton - Valentine leukocidin

  • A. Badarau, Z. C. Visram, +5 authors M. Zerbs
  • GENES
  • 2015

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