Differential Inhibitory Effects of Cholera Toxoids and Ganglioside on the Enterotoxins of Vibrio Cholerae and Escherichia Coli

Abstract

Natural cholera toxoid appears to act as a competitive inhibitor of cholera enterotoxin and is thus a useful tool for studying the interaction of cholera enterotoxin with cell membranes. Cholera enterotoxin binds to gut mucosa more rapidly than does its natural toxoid. Once binding occurs, however, it appears to be prolonged for both materials. Formalinized… (More)

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