Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors

@inproceedings{Ran2015DifferentialIO,
  title={Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors},
  author={Yong Ran and Gabriela Z. Ladd and Carolina Ceballos-Diaz and Joo In Jung and Doron Greenbaum and Kevin M. Felsenstein and Todd E Golde and Stephen D Ginsberg},
  booktitle={PloS one},
  year={2015}
}
The signal peptide peptidases (SPPs) are biomedically important proteases implicated as therapeutic targets for hepatitis C (human SPP, (hSPP)), plasmodium (Plasmodium SPP (pSPP)), and B-cell immunomodulation and neoplasia (signal peptide peptidase like 2a, (SPPL2a)). To date, no drug-like, selective inhibitors have been reported. We use a recombinant substrate based on the amino-terminus of BRI2 fused to amyloid β 1-25 (Aβ1-25) (FBA) to develop facile, cost-effective SPP/SPPL protease assays… CONTINUE READING