Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.

@article{Liu2011DifferentialIS,
  title={Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.},
  author={Sue Min Liu and David H. Lee and Jenna M Sullivan and Denise T Chung and Anneli J{\"a}ger and Bennett O. V. Shum and Nora E. Sarvetnick and Ana Carrizossa Anderson and Vijay K Kuchroo},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 11},
  pages={4303-10}
}
Type 1 diabetes (T1D) is an autoimmune disease that shows familial aggregation in humans and likely has genetic determinants. Disease linkage studies have revealed many susceptibility loci for T1D in mice and humans. The mouse T1D susceptibility locus insulin-dependent diabetes susceptibility 3 (Idd3), which has a homologous genetic interval in humans, encodes cytokine genes Il2 and Il21 and regulates diabetes and other autoimmune diseases; however, the cellular and molecular mechanisms of this… CONTINUE READING

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