Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

@inproceedings{Norrholm2013DifferentialGA,
  title={Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder},
  author={Seth D. Norrholm and Tanja Jovanovic and Alicia K. Smith and Elisabeth B. Binder and Torsten Klengel and Karen N. Conneely and Kristina B. Mercer and Jennifer S. Davis and Kimberly Kerley and Jennifer S Winkler and Charles F Gillespie and Bekh Bradley and Kerry J. Ressler},
  booktitle={Front. Behav. Neurosci.},
  year={2013}
}
The catechol-O-methyltransferase (COMT) enzyme is critical for the catabolic regulation of synaptic dopamine, resulting in altered cortical functioning. The COMT Val(158)Met polymorphism has been implicated in human mental illness, with Met/Met homozygotes associated with increased susceptibility to posttraumatic stress disorder (PTSD). Our primary objective was to examine the intermediate phenotype of fear inhibition in PTSD stratified by COMT genotype (Met/Met, Val/Met, and Val/Val) and… CONTINUE READING
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PTSD and gene

  • B. Davino
  • 2012

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