Differential General Anesthetic Effects on Microglial Cytokine Expression

@inproceedings{Ye2013DifferentialGA,
  title={Differential General Anesthetic Effects on Microglial Cytokine Expression},
  author={Xuefei Ye and Qingquan Lian and Maryellen Fazen Eckenhoff and Roderic G. Eckenhoff and Jonathan Z. Pan},
  booktitle={PloS one},
  year={2013}
}
Post-operative cognitive dysfunction has been widely observed, especially in older patients. An association of post-operative cognitive dysfunction with the neurodegenerative diseases, such as Alzheimer's disease, has been suggested. Neuroinflammation contributes to Alzheimer pathology, through elevated pro-inflammatory cytokines and microglial activation in the CNS leading to neuronal damage, synaptic disruption and ultimately cognitive dysfunction. We compare the effects of three different… CONTINUE READING

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