Differential Gene Expression of TGF-β Family Members and Osteopontin in Breast Tumor Tissue: Analysis by Real-Time Quantitative PCR

@article{Reinholz2004DifferentialGE,
  title={Differential Gene Expression of TGF-β Family Members and Osteopontin in Breast Tumor Tissue: Analysis by Real-Time Quantitative PCR},
  author={Monica M. Reinholz and Stephen J. Iturria and James N. Ingle and Patrick C. Roche},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={74},
  pages={255-269}
}
Several cytokines including members of the transforming growth factor-beta (TGF-β) and tumor necrosis factor (TNF) families have been implicated in the homing mechanism of breast cancer metastasis. We hypothesize that primary breast tumor tissues differentially express modulators of bone cell function and that this expression pattern contributes to their aggressive and metastatic potential and to their capacity to establish and grow in bone. We, therefore, examined the gene expression pattern… CONTINUE READING