Differential Functions of the C. elegans FGF Receptor in Axon Outgrowth and Maintenance of Axon Position

@article{Blow2004DifferentialFO,
  title={Differential Functions of the C. elegans FGF Receptor in Axon Outgrowth and Maintenance of Axon Position},
  author={Hannes E B{\"u}low and Thomas Boulin and Oliver Hobert},
  journal={Neuron},
  year={2004},
  volume={42},
  pages={367-374}
}
Wiring of the nervous system requires that axons navigate to their targets and maintain their correct positions in axon fascicles after termination of axon outgrowth. We show here that the C. elegans fibroblast growth factor receptor (FGFR), EGL-15, affects both processes in fundamentally distinct manners. FGF-dependent activation of the EGL-15 tyrosine kinase and subsequently the GTPase LET-60/ras is required within epidermal cells, the substratum for most outgrowing axon, for appropriate… CONTINUE READING
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