Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines

  title={Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines},
  author={Marta Reyes-Corral and Naja M{\o}ller M. S{\o}rensen and Christopher Thrasivoulou and Prokar Dasgupta and Jonathan F Ashmore and Aamir Ahmed},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  pages={152 - 162}
Class II antiarrhythmics or β-blockers are antisympathetic nervous system agents that act by blocking β-adrenoceptors. Despite their common clinical use, little is known about the effects of β-blockers on free intracellular calcium (Ca2+i), an important cytosolic second messenger and a key regulator of cell function. We investigated the role of four chemical analogs, commonly prescribed β-blockers (atenolol, metoprolol, propranolol, and sotalol), on Ca2+i release and whole-cell currents in… 

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