Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells.

@article{StPierre2015DifferentialFO,
  title={Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells.},
  author={Charles St-Pierre and Assya Trofimov and Sylvie Brochu and S{\'e}bastien Lemieux and Claude Perreault},
  journal={Journal of immunology},
  year={2015},
  volume={195 2},
  pages={498-506}
}
Establishment of self-tolerance in the thymus depends on promiscuous expression of tissue-restricted Ags (TRA) by thymic epithelial cells (TEC). This promiscuous gene expression (pGE) is regulated in part by the autoimmune regulator (AIRE). To evaluate the commonalities and discrepancies between AIRE-dependent and -independent pGE, we analyzed the transcriptome of the three main TEC subsets in wild-type and Aire knockout mice. We found that the impact of AIRE-dependent pGE is not limited to… CONTINUE READING
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