Differential Expression of Redox Factor-1 Associated with Beta-Amyloid-Mediated Neurotoxicity.

@article{Tan2009DifferentialEO,
  title={Differential Expression of Redox Factor-1 Associated with Beta-Amyloid-Mediated Neurotoxicity.},
  author={Zhiqun Tan and Lei Shi and S. Shotkin HJ. Schreiber},
  journal={The open neuroscience journal},
  year={2009},
  volume={3},
  pages={26-34}
}
Redox factor-1 (Ref-1), also known as HAP1, APE or APEX, is a multifunctional protein that regulates gene transcription as well as the response to oxidative stress. By interacting with transcription factors such as AP-1, NF-kappaB and p53, and directly participating in the cleavage of apurininic/apyrimidinic DNA lesions, Ref-1 plays crucial roles in both cell death signaling pathways and DNA repair, respectively. Oxidative stress induced by aggregated beta-amyloid (Abeta) peptide, altered DNA… CONTINUE READING