Differential Expression of Metallothioneins in Human Prion Diseases

@article{Kawashima2000DifferentialEO,
  title={Differential Expression of Metallothioneins in Human Prion Diseases},
  author={Toshiro Kawashima and Katsumi Doh-Ura and Miho Torisu and Yoko Uchida and Akiko Furuta and Toru Iwaki},
  journal={Dementia and Geriatric Cognitive Disorders},
  year={2000},
  volume={11},
  pages={251 - 262}
}
  • Toshiro Kawashima, Katsumi Doh-Ura, +3 authors Toru Iwaki
  • Published in
    Dementia and Geriatric…
    2000
  • Medicine, Biology
  • We herein report an immunohistochemical and a Western blot analysis on metal/free radical chelating proteins, metallothioneins (MTs; MT-I/II and MT-III), in the brains of human prion disease patients with or without prion protein gene mutation and polymorphism. Irrespective of the isoforms of MTs, the immunoreaction was detected in the cytoplasm and processes of the astrocytes in the cerebral cortex and white matter in normal controls and prion disease brains. Although the immunoreactivities… CONTINUE READING

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