Differential Expression of Genes Involved in Early Events of Spermatogenesis in Mice

@article{Ketkar2013DifferentialEO,
  title={Differential Expression of Genes Involved in Early Events of Spermatogenesis in Mice},
  author={Alhad Ashok Ketkar and K V R Reddy},
  journal={Journal of Cell Science and Therapy},
  year={2013},
  volume={4},
  pages={1-8}
}
Spermatogenesis is a highly complex process involved in the transmission of genetic information from one generation to next generation. The process takes place in the seminiferous tubules of the testis and is regulated by genes that control cell division, cell-cell interaction and morphogenetic changes in both the somatic and germ cell lineages in a highly orchestrated pattern. The first wave of spermatogenesis in mouse is typically characterized by the differential expression of genes involved… 
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References

SHOWING 1-10 OF 45 REFERENCES
Expression Pattern of OCT-4 and PLZF Transcription Factors during the Early Events of Spermatogenesis in Mice
TLDR
The present study reveals the expression pattern of Oct-4 and Plzf in the early stages of spermatogenesis of mice which sets the basis of sPermatogenesis process in adults.
Microarray-Based Analysis of Cell-Cycle Gene Expression During Spermatogenesis in the Mouse1
TLDR
It is suggested that distinct cell-cycle gene regulatory networks or subnetworks are associated with each phase of the cell cycle in each spermatogenic cell type.
The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis1
TLDR
A developmental testis gene expression time course profiling the expression patterns of ∼36 000 transcripts on the Affymetrix MGU74v2 GeneChip platform at 11 distinct time points was created to gain a greater understanding of the molecular changes necessary for and elicited by the development of the testis.
5 Gene Expression during Mammalian Meiosis
Effect of Oct-4 Silencing on Proliferation and Differentiation of Mouse Undifferentiated Type A Spermatogonial Cells
TLDR
It is suggested that Oct-4 does play an important role in deciding the fate of undifferentiated spermatogonia by controlling their proliferation and differentiation by shRNA mediated gene silencing approach.
Gene expression during mammalian meiosis.
TLDR
Drawing mainly on studies in spermatogenesis, this review shows that some of these genes are transcribed exclusively in germ cells, while others are also transcribed in somatic cells.
Identifying genes important for spermatogonial stem cell self-renewal and survival.
TLDR
Comparison of data generated in this study to other stem cell types suggests that self-renewal in SSCs is regulated by distinctly different molecular mechanisms.
Age affects gene expression in mouse spermatogonial stem/progenitor cells.
TLDR
The expression levels of the genes encoding the SSC markers Gfra1 and Plzf did not seem to be significantly altered by age, indicating that age affects only certain SSC/progenitor properties.
Male germ cell gene expression.
  • E. M. Eddy
  • Biology
    Recent progress in hormone research
  • 2002
TLDR
Male germ cell development consists of an assortment of unique processes, including meiosis, genetic recombination, haploid gene expression, formation of the acrosome and flagellum, and remodeling and condensation of the chromatin.
Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene.
TLDR
The phenotype of mice in which targeted disruption of the act gene was obtained by homologous recombination indicates that numerous postmeiotic genes under CREM control require the coactivator function of ACT, and fine-tuning of sperm development is achieved by the coordinated action of two transcriptional regulators.
...
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