Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

@inproceedings{Nashine2016DifferentialEO,
  title={Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids},
  author={Sonali R Nashine and Marilyn Chwa and Mina Kazemian and Kunal H. Thaker and Stephanie Lu and Anthony B. Nesburn and Baruch D. Kuppermann and Macauley Kenney},
  booktitle={PloS one},
  year={2016}
}
PURPOSE Variations in mitochondrial DNA (mtDNA) and abnormalities in the complement pathways have been implicated in the pathogenesis of age-related macular degeneration (AMD). This study was designed to determine the effects of mtDNA from AMD subjects on the complement pathway. METHODS Transmitochondrial cybrids were prepared by fusing platelets from AMD and age-matched Normal subjects with Rho0 (lacking mtDNA) human ARPE-19 cells. Quantitative PCR and Western blotting were performed to… CONTINUE READING

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