Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer.

@article{Schalper2017DifferentialEA,
  title={Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer.},
  author={Kurt Alex Schalper and Daniel E. Carvajal-Hausdorf and Joseph F McLaughlin and Mehmet Orhan Altan and Vamsidhar Velcheti and Patricia Gaule and Miguel F Sanmamed and Lieping Chen and Roy S. Herbst and David L. Rimm},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2017},
  volume={23 2},
  pages={370-378}
}
PURPOSE To determine the expression level, associations, and biological role of PD-L1, IDO-1, and B7-H4 in non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN Using multiplexed quantitative immunofluorescence (QIF), we measured the levels of PD-L1, IDO-1, B7-H4, and different tumor-infiltrating lymphoycte (TIL) subsets in 552 stages I-IV lung carcinomas from two independent populations. Associations between the marker levels, TILs, and major clinicopathologic variables were determined… CONTINUE READING
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