Differential Epstein-Barr virus gene expression in B-cell subsets recovered from lymphomas in SCID mice after transplantation of human peripheral blood lymphocytes.

@article{Rochford1995DifferentialEV,
  title={Differential Epstein-Barr virus gene expression in B-cell subsets recovered from lymphomas in SCID mice after transplantation of human peripheral blood lymphocytes.},
  author={Rosemary Rochford and Donald E. Mosier},
  journal={Journal of virology},
  year={1995},
  volume={69 1},
  pages={150-5}
}
We have analyzed the human B-cell tumors that arise spontaneously in SCID mice who have been given transplants of peripheral blood lymphocytes from Epstein-Barr virus (EBV)-seropositive donors to determine if patterns of EBV gene expression are correlated with phenotypic changes in the tumor B cells. Tumor cells were separated into two B-cell subsets by cell sorting on the basis of differential coexpression of membrane CD23 and CD38. One subset showed intermediate levels of CD23 and CD38… CONTINUE READING

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Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation

  • K. M. Kaye, K. M. Isuzmi, E. Kieff
  • Proc. Natl. Acad. Sci. USA
  • 1993
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