Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia

@article{Bettica2012DifferentialEO,
  title={Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia},
  author={P. Bettica and L. Squassante and J. Groeger and B. Gennery and R. Winsky-Sommerer and D. Dijk},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={1224-1233}
}
  • P. Bettica, L. Squassante, +3 authors D. Dijk
  • Published 2012
  • Medicine, Psychology
  • Neuropsychopharmacology
  • Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single doses of the dual orexin receptor antagonist SB-649868 (10 or 30 mg) and a positive control zolpidem (10 mg), an allosteric modulator of GABAA receptors. Objective and subjective sleep parameters and next-day performance were assessed in 51 healthy… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 52 REFERENCES
    A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
    • 13,230
    Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
    • 2,617
    • Open Access
    Promotion of sleep by targeting the orexin system in rats, dogs and humans
    • 456
    Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
    • 699
    • Open Access
    Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
    • 1,060
    • Open Access
    Sleep Deprivation and Vigilant Attention
    • 752
    • Open Access
    Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists.
    • 196
    • Open Access
    The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats
    • 319
    Orexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomammillary Nucleus
    • 454
    • Open Access