Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells

@article{Hu2012DifferentialEO,
  title={Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells},
  author={Yang Hu and Kevin Kyungsuk Park and Liu Yang and Xin Wei and Qiang Yang and Kin-Sang Cho and Peter Thielen and Ann-Hwee Lee and Romain Cartoni and L. H. Glimcher and Dong Feng Chen and Zhigang He},
  journal={Neuron},
  year={2012},
  volume={73},
  pages={445-452}
}
Loss of retinal ganglion cells (RGCs) accounts for visual function deficits after optic nerve injury, but how axonal insults lead to neuronal death remains elusive. By using an optic nerve crush model that results in the death of the majority of RGCs, we demonstrate that axotomy induces differential activation of distinct pathways of the unfolded protein response in axotomized RGCs. Optic nerve injury provokes a sustained CCAAT/enhancer binding homologous protein (CHOP) upregulation, and… CONTINUE READING