Differential Effects of Three Inhibitors of Glycosphingolipid Biosynthesis on Neuronal Differentiation of Embryonal Carcinoma Stem Cells

@article{Liour2002DifferentialEO,
  title={Differential Effects of Three Inhibitors of Glycosphingolipid Biosynthesis on Neuronal Differentiation of Embryonal Carcinoma Stem Cells},
  author={Sean S. Liour and Robert K. Yu},
  journal={Neurochemical Research},
  year={2002},
  volume={27},
  pages={1507-1512}
}
Gangliosides have been implicated in having important roles in neural development. It has been shown that disruption of ganglioside biosynthesis inhibits neurite outgrowth. However, many contradictory results have been reported. The inconsistency of these reports may result from the differential use of neuronal cell lines and inhibitors for ganglioside biosynthesis. In order to clarify the inconsistency in these studies, we utilized an in vitro neuronal differentiation model using an embryonic… CONTINUE READING
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