Differential Effects of Short-Term Treatment with Two AT1 Receptor Blockers on Diameter of Pial Arterioles in SHR

@inproceedings{Foulquier2012DifferentialEO,
  title={Differential Effects of Short-Term Treatment with Two AT1 Receptor Blockers on Diameter of Pial Arterioles in SHR},
  author={S{\'e}bastien Foulquier and François Dupuis and Caroline Perrin-Sarrado and Katy Maguin Gat{\`e} and Pierre Leroy and P. Caparr{\'o}s Limi{\~n}ana and Jeffrey Lansing Atkinson and C. Capdeville-atkinson and Isabelle Lartaud},
  booktitle={PloS one},
  year={2012}
}
Chronic treatment with angiotensin receptor blockers is largely accepted for protecting cerebral circulation during hypertension, but beneficial effects of short-term treatments are questionable, as highlighted by the recent SCAST trial. We compared the impact of 10 days treatment with candesartan (as SCAST) versus telmisartan (previously described to reverse arteriolar remodeling, chronic treatment) on pial arterioles of spontaneously hypertensive rats (SHR). We explored whether PPAR-gamma… CONTINUE READING

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