Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat

@inproceedings{Zhang2012DifferentialEO,
  title={Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat},
  author={Jian Zhang and Oxana P. Lazarenko and Xianli Wu and Yudong Tong and Michael L. Blackburn and Horatio Gomez-Acevedo and Kartik Shankar and T M Badger and Martin J. J. Ronis and J Chen},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Previous reports suggest that beneficial effects of soy on bone quality are due to the estrogenic actions of isoflavone phytochemicals associated with the protein. However, mechanistic studies comparing the effects of soy diet and estrogens on bone, particularly in rapidly growing animals are lacking. METHODOLOGY AND PRINCIPAL FINDINGS We studied the effects of short term feeding of soy protein isolate (SPI) on bone in comparison to the effects of 17β-estradiol (E2) in pre-pubertal… CONTINUE READING