Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.

@article{Chen2016DifferentialEO,
  title={Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.},
  author={Justin L. Chen and Kelly L. Walton and Hongwei Qian and Timothy D. Colgan and Adam Hagg and Matthew J Watt and Craig A Harrison and Paul Gregorevic},
  journal={Cancer research},
  year={2016},
  volume={76 18},
  pages={5372-82}
}
Cachexia is a life-threatening wasting syndrome lacking effective treatment, which arises in many cancer patients. Although ostensibly induced by multiple tumor-produced cytokines (tumorkines), their functional contribution to initiation and progression of this syndrome has proven difficult to determine. In this study, we used adeno-associated viral vectors to elevate circulating levels of the tumorkines IL6 and/or activin A in animals in the absence of tumors as a tactic to evaluate… CONTINUE READING
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