Differential Effects of DOCA on Renal and Gastrointestinal Handling of Sodium and Potassium in Pigs

  title={Differential Effects of DOCA on Renal and Gastrointestinal Handling of Sodium and Potassium in Pigs},
  author={M. E. Grigorian and Roger J. Grekin and J C Mitchell and S P Dybus and J Buiteweg and David F. Bohr},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={265 - 269}
Abstract Young, male pigs eating standard pig chow, ad libitum, received approximately 170 mEq Na and 290 mEq K per day. Electrolyte intake, urinary and fecal electrolyte output, and plasma electrolyte levels were determined daily in 12 deoxycorticosterone acetate (DOCA)-treated pigs and in 6 control pigs. Daily Na and K balances (dietary intake – urinary + fecal output) were calculated. DOCA caused a reduction in urinary Na output from 1.53 mEq/kg/day to 0.57 mEq/kg/day during the first 48 hr… 

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