Differential Effects of CB1 and Opioid Agonists on Two Populations of Adult Rat Dorsal Root Ganglion Neurons

@article{Khasabova2004DifferentialEO,
  title={Differential Effects of CB1 and Opioid Agonists on Two Populations of Adult Rat Dorsal Root Ganglion Neurons},
  author={Iryna A. Khasabova and Catherine Harding-Rose and Donald A. Simone and Virginia S. Seybold},
  journal={The Journal of Neuroscience},
  year={2004},
  volume={24},
  pages={1744 - 1753}
}
  • Iryna A. Khasabova, Catherine Harding-Rose, +1 author Virginia S. Seybold
  • Published 2004
  • Biology, Medicine
  • The Journal of Neuroscience
  • Inhibition of primary afferent neurons contributes to the antihyperalgesic effects of opioid and CB1 receptor agonists. Two bioassays were used to compare the effects of the CB1 receptor agonist CP 55,940 and morphine on dissociated adult rat DRG neurons. Both agonists inhibited the increase in free intracellular Ca2+ concentration evoked by depolarization; however, effects of CP 55,940 occurred primarily in large neurons (cell area, >800 μm2), whereas morphine inhibited the response in smaller… CONTINUE READING

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