Differential Effects of σ1 Receptor Blockade on Self-Administration and Conditioned Reinstatement Motivated by Cocaine vs Natural Reward


Growing evidence suggests a role for sigma1 (σ1) receptors in cognitive function, anxiety, depression, regulation of stress responses, and, recently, the appetitive effects of cocaine as measured by conditioned place preference. This study was designed to extend understanding of the role of σ1 receptors in addiction-relevant conditioned effects of cocaine… (More)
DOI: 10.1038/sj.npp.1301323


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