Differential Effects of Δ9-Tetrahydrocannabinol and Methanandamide in CB1 Knockout and Wild-Type Mice

@article{Baskfield2004DifferentialEO,
  title={Differential Effects of $\Delta$9-Tetrahydrocannabinol and Methanandamide in CB1 Knockout and Wild-Type Mice},
  author={Cassandra Y. Baskfield and Billy R. Martin and Jenny L. Wiley},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={309},
  pages={86 - 91}
}
Mice devoid of CB1 cannabinoid receptors (CB1-/- mice) provide a unique opportunity to further investigate the role of CB1 receptors in exocannabinoid and endocannabinoid effects. CB1-/- mice (N = 18) and their wild-type littermates (CB1+/+ mice; N = 12) were placed in standard mouse operant chambers and trained to lever press under a fixed ratio 10 schedule of reinforcement. When stable lever press responding under the fixed ratio 10 schedule had been established, cannabinoids and… 

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